abstract：:Chronic exposure to Mn results in the development of a neurological disorder known as manganism characterized by neurological deficits resembling that seen in Parkinsonism. Although dopaminergic neurons within the nigrostriatal pathway appear intact, Mn-induced irregularities in DA transmission have been observed incl...

journal_title：Neurotoxicology

authors： Roth JA,Li Z,Sridhar S,Khoshbouei H

更新日期：2013-03-01 00:00:00

abstract：:Snake venom group IA secretory phospholipase A2 (sPLA2-IA) is known as a neurotoxin. Snake venom sPLA2s are neurotoxic in vivo and in vitro, causing synergistic neurotoxicity to cortical cultures when applied with toxic concentrations of glutamate. However, it has not yet been cleared sufficiently how sPLA2-IA exerts ...

journal_title：Neurotoxicology

authors： Yagami T,Yamamoto Y,Kohma H,Nakamura T,Takasu N,Okamura N

更新日期：2013-03-01 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease (AD), aggregation and deposition of amyloid-β peptides, has been recognized as a potent activator of microglia-mediated neuroinflammation and neuronal dysfunction. Therefore, downregulation of microglial activation has a significant therapeutic demand. In this study, focu...

journal_title：Neurotoxicology

authors： Dewapriya P,Li YX,Himaya SW,Pangestuti R,Kim SK

更新日期：2013-03-01 00:00:00

abstract：:Deoxynivalenol (DON), produced by the cereal-contaminating Fusarium fungi, is a major trichothecene responsible for mycotoxicoses in farm animals, including swine. The main effect of DON-intoxication is food intake reduction and the consequent body weight loss. The present study aimed to identify brain structures acti...

journal_title：Neurotoxicology

authors： Gaigé S,Bonnet MS,Tardivel C,Pinton P,Trouslard J,Jean A,Guzylack L,Troadec JD,Dallaporta M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:While the impact of active maternal smoking during pregnancy on child health has been well investigated, the association between maternal passive smoking, or environmental tobacco smoke (ETS), or second-hand smoke, and behavioral development of offspring is less clear. This study examines the association bet...

journal_title：Neurotoxicology

authors： Liu J,Leung PW,McCauley L,Ai Y,Pinto-Martin J

更新日期：2013-01-01 00:00:00

abstract：:N-Butylbenzenesulfonamide (NBBS) is widely used as a plasticizer in polyacetals, polyamides, and polycarbonates and has been found in ground water and effluent from wastewater treatment sites. The compound is lipophilic and distributes rapidly to the brain but also clears rapidly and shows little evidence of accumulat...

journal_title：Neurotoxicology

authors： Rider CV,Janardhan KS,Rao D,Morrison JP,McPherson CA,Harry GJ

更新日期：2012-12-01 00:00:00

abstract：:It has been suggested that exposure to pesticides might be involved in the etiology of Parkinson's disease (PD). We conducted an updated systematic review of the epidemiologic literature over the past decade on the relationship between pesticide exposure and PD, using the MEDLINE database. Despite methodological diffe...

journal_title：Neurotoxicology

authors： Freire C,Koifman S

更新日期：2012-10-01 00:00:00

abstract：:The Inuit from Nunavik (Northern Québec) are one of the most highly exposed populations to environmental contaminants in North America mainly due to the bioaccumulation of contaminants in fish and marine mammals that constitute an important part of their diet. This follow-up study aimed to assess the impact of exposur...

journal_title：Neurotoxicology

authors： Ethier AA,Muckle G,Bastien C,Dewailly É,Ayotte P,Arfken C,Jacobson SW,Jacobson JL,Saint-Amour D

更新日期：2012-10-01 00:00:00

abstract：:Neuron-specific in vitro screening strategies have the potential to accelerate the evaluation of chemicals for neurotoxicity. We examined neurite outgrowth as a measure of neuronal response with a commercially available rat cortex progenitor cell model, where cells were exposed to a chemical during a period of cell di...

journal_title：Neurotoxicology

authors： Jeerage KM,Oreskovic TL,Hume SL

更新日期：2012-10-01 00:00:00

abstract：AIM:This study examined the acute effects of severe monocrotophos (MCP) poisoning on AChE inhibition, mRNA expression and recovery of acetylcholinesterase activity in different regions of the rat brain. STUDY:Wistar rats were administered monocrotophos (0.8LD(50)) by oral gavage to elicit severe effects of acute poiso...

journal_title：Neurotoxicology

authors： Kazi AI,Oommen A

更新日期：2012-10-01 00:00:00

abstract：:Nerve agents are deadly threats to military and civilian populations around the world. Nerve agents cause toxicity to peripheral and central sites through the irreversible inhibition of acetylcholinesterase, the enzyme that metabolizes acetylcholine. Excessive acetylcholine accumulation in synapses results in status e...

journal_title：Neurotoxicology

authors： Pan H,Hu XZ,Jacobowitz DM,Chen C,McDonough J,Van Shura K,Lyman M,Marini AM

更新日期：2012-10-01 00:00:00

abstract：:Worldwide, n-hexane is an organic solvent widely used in numerous industries such as chemical engineering, pharmaceutical and cosmetic industry. 2,5-Hexanedione (2,5-HD) is the main metabolite of n-hexane. It is now gradually recognized that chronic exposure to n-hexane could harm the health of people. Nevertheless, i...

journal_title：Neurotoxicology

authors： Cheng X,Wang G,Ma ZL,Chen YY,Fan JJ,Zhang ZL,Lee KK,Luo HM,Yang X

更新日期：2012-10-01 00:00:00

abstract：:Mouse embryonic stem cells (mESCs) represent an attractive cellular system for in vitro studies in developmental biology as well as toxicology because of their potential to differentiate into all fetal cell lineages. The present study aims to establish an in vitro system for developmental neurotoxicity testing employi...

journal_title：Neurotoxicology

authors： Visan A,Hayess K,Sittner D,Pohl EE,Riebeling C,Slawik B,Gulich K,Oelgeschläger M,Luch A,Seiler AE

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Resin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children. OBJECTIVES:To examine whether exposure to resin-based composite restorations is associated with neuropsychological de...

journal_title：Neurotoxicology

authors： Maserejian NN,Trachtenberg FL,Hauser R,McKinlay S,Shrader P,Bellinger DC

更新日期：2012-10-01 00:00:00

abstract：:For the diagnosis of patients suspected of chronic solvent-induced encephalopathy (CSE), it would be helpful if the applied cognitive tests show a characteristic profile of impairment in this disease. We investigated the existence of such a profile. In 1997-2006 two expert teams in The Netherlands systematically exami...

journal_title：Neurotoxicology

authors： Verberk MM,van der Hoek JA,van Valen E,Wekking EM,van Hout MS,Hageman G,van der Laan G,van Dijk FJ

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Long-term exposure to organic solvents may lead to chronic solvent induced encephalopathy (CSE) in painters. In combination with reduction of exposure, a workers' health surveillance programme was developed, resulting in a three-stage CSE screening procedure for early neurobehavioural changes possibly predic...

journal_title：Neurotoxicology

authors： Spee T,van Valen E,van Duivenbooden C,van der Laan G

更新日期：2012-08-01 00:00:00

abstract：:Methylmercury (MeHg) is an environmental neurotoxicant associated with aberrant central nervous system (CNS) functions. In this study, we examined the protective effect of a novel anti-inflammatory and cytoprotective nonapeptide, termed IIIM1, against MeHg-induced toxicity in cultured rat neonatal primary astrocytes. ...

journal_title：Neurotoxicology

authors： Wormser U,Brodsky B,Milatovic D,Finkelstein Y,Farina M,Rocha JB,Aschner M

更新日期：2012-08-01 00:00:00

abstract：:The occurrence of status epilepticus (SE) is considered the main cause of brain lesions and morphological alterations, such as hippocampal neuron loss, that result in chronic epilepsy. Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes ...

journal_title：Neurotoxicology

authors： Rossetti F,de Araujo Furtado M,Pak T,Bailey K,Shields M,Chanda S,Addis M,Robertson BD,Moffett M,Lumley LA,Yourick DL

更新日期：2012-06-01 00:00:00

abstract：:Methylmercury (MeHg) exposure at high concentrations poses significant neurotoxic threat to humans worldwide. The present study investigated the mechanisms of glutathione-mediated attenuation of MeHg neurotoxicity in primary cortical culture. MeHg (5 μM) caused depletion of mono- and disulfide glutathione in neuronal,...

journal_title：Neurotoxicology

authors： Rush T,Liu X,Nowakowski AB,Petering DH,Lobner D

更新日期：2012-06-01 00:00:00

abstract：:Chaperones in the endoplasmic reticulum play vital roles in the folding, assembly, and post-translational modification of secretory proteins and also recycle, refold, or initiate degradation of misfolded proteins. Chaperone deficiencies in either amount or function are implicated in the etiology or pathogenesis of Alz...

journal_title：Neurotoxicology

authors： Tiffany-Castiglioni E,Qian Y

更新日期：2012-06-01 00:00:00

abstract：:Neuroinflammation and microglia as the resident immune cells of the brain has garnered a significant amount of interest with regards to brain injury and neurotoxicology. Much of this interest and research has been focused on responses in the adult brain with little attention paid to the role of these cells during deve...

journal_title：Neurotoxicology

authors： Harry GJ

更新日期：2012-06-01 00:00:00

abstract：:The chemical warfare nerve agent, soman irreversibly inhibits acetylcholinesterase (AChE) leading to hypercholinergy and seizures which trigger glutamate toxicity and status epilepticus ultimately resulting in neuropathology and neurobehavioral deficits. The standard emergency treatment comprising of anticholinergic, ...

journal_title：Neurotoxicology

authors： Wang Y,Oguntayo S,Wei Y,Wood E,Brown A,Jensen N,Auta J,Guiodotti A,Doctor BP,Nambiar MP

更新日期：2012-03-01 00:00:00

abstract：:Drinking water manganese (WMn) is a potential threat to children's health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects. Although adverse effects of Mn on cognitive function of the children indicate possible impact on their academic achievement lit...

journal_title：Neurotoxicology

authors： Khan K,Wasserman GA,Liu X,Ahmed E,Parvez F,Slavkovich V,Levy D,Mey J,van Geen A,Graziano JH,Factor-Litvak P

更新日期：2012-01-01 00:00:00

abstract：:Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although genetic mutations in ion channels and receptors and some other risk factors such as brain injury are linked to epileptogenesis, the underlying cause for the majority of epilepsy cases remains unknown. Gene-environment inte...

journal_title：Neurotoxicology

authors： Yuan Y

更新日期：2012-01-01 00:00:00

abstract：:Ethanol is a widely consumed drug that acts on the central nervous system (CNS), modifying several signal transduction pathways activated by hormones and neurotransmitters. The zebrafish is an experimental model for the study of human diseases and the use of this species in biochemical and behavioral studies on alcoho...

journal_title：Neurotoxicology

authors： Rico EP,Rosemberg DB,Langoni Ada S,Souto AA,Dias RD,Bogo MR,Bonan CD,Souza DO

更新日期：2011-12-01 00:00:00

abstract：:Selenium (Se) is a well-known anti-oxidant with a critical role in the proper functioning of nervous and muscle functions. Se deficiency has been associated with both cognitive and neuromotor impairment, while sensory and motor deficits have been attributed to excess Se. In the Lower Tapajós Region of the Brazilian Am...

journal_title：Neurotoxicology

authors： Lemire M,Fillion M,Frenette B,Passos CJ,Guimarães JR,Barbosa F Jr,Mergler D

更新日期：2011-12-01 00:00:00

abstract：:Drugs of abuse are known to mainly affect the dopaminergic and serotonergic system, although behavioral studies indicated that the GABA-ergic system also plays a role. We therefore investigated the acute effects of several commonly used drugs of abuse (methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (M...

journal_title：Neurotoxicology

authors： Hondebrink L,Meulenbelt J,van Kleef RG,van den Berg M,Westerink RH

更新日期：2011-12-01 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of methylmercury (MeHg) neurotoxicity. Studies of mature neurons suggest that the mitochondrion may be a major source of MeHg-induced reactive oxygen species and a critical mediator of MeHg-induced neuronal death, likely by activation of apoptotic pathways. It i...

journal_title：Neurotoxicology

authors： Polunas M,Halladay A,Tjalkens RB,Philbert MA,Lowndes H,Reuhl K

更新日期：2011-10-01 00:00:00

abstract：:There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the δ-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage batte...

journal_title：Neurotoxicology

authors： Zheng G,Tian L,Liang Y,Broberg K,Lei L,Guo W,Nilsson J,Bergdahl IA,Skerfving S,Jin T

更新日期：2011-08-01 00:00:00

abstract：:Parkinson's disease (PD) is frequently reported to be associated with pesticide exposure but the issue has not yet been solved because the data are inconsistent and the studies suffer from several biases and limitations. The aim of this article is to summarise available biochemical and toxicological data on some pesti...

journal_title：Neurotoxicology

authors： Moretto A,Colosio C

更新日期：2011-08-01 00:00:00

abstract：:To evaluate the role of diet composition on nerve agent toxicity, rats were fed four distinct diets ad libitum for 28 d prior to challenge with 110 μg/kg (1.0 LD(50), sc) soman. The four diets used were a standard rodent diet, a choline-enriched diet, a glucose-enriched diet, and a ketogenic diet. Body weight was reco...

journal_title：Neurotoxicology

authors： Myers TM,Langston JL

更新日期：2011-06-01 00:00:00

abstract：:The present studies were conducted to changes arising from mercury poisoning in the central nervous system (CNS), with a focus on determining the receptors and neurotransmitters involved. Currently, little is known regarding the neurological basis of the cardiopulmonary effects of mercury poisoning. We evaluated chang...

journal_title：Neurotoxicology

authors： Azevedo BF,Futuro Neto Hde A,Stefanon I,Vassallo DV

更新日期：2011-06-01 00:00:00

abstract：:Application of the widely used immunosuppressant (ISS) cyclosporine (CsA) is severely limited by a number of serious side-effects such as kidney and neurotoxicity. As we have shown before, CsA exhibits metabolic toxicity in brain-models. The macrolide ISSs sirolimus (SRL) and everolimus (RAD) are capable of modulating...

journal_title：Neurotoxicology

authors： Gottschalk S,Cummins CL,Leibfritz D,Christians U,Benet LZ,Serkova NJ

更新日期：2011-01-01 00:00:00

abstract：:In order to shorten the list of candidate drugs with anticonvulsant potential against nerve agents, critical subreceptors in seizure controlling brain regions should be specified. Epileptiform activity does not spread randomly throughout the brain, but appears to be generated and propagated by specific anatomical rout...

journal_title：Neurotoxicology

authors： Myhrer T

更新日期：2010-12-01 00:00:00

abstract：:The early effects of 6-OHDA as a Parkinsonian model in rodents are relevant since pharmacological and toxicological points of view, as they can explain the acute and chronic deleterious events occurring in the striatum. In this study, we focused our attention on the neurochemical and motor dysfunction produced after a...

journal_title：Neurotoxicology

authors： Tobón-Velasco JC,Silva-Adaya D,Carmona-Aparicio L,García E,Galván-Arzate S,Santamaría A

更新日期：2010-12-01 00:00:00

abstract：:This study investigated the effect of the pre- and perinatal exposure to di-(2-ethylhexyl) phthalate (DEHP) on the neuroendocrine parameters that regulate reproduction in peripubertal male rats. DEHP at dose of 3 and 30mg/kg bw/day was administered orally to female rat since pregnancy onset until weaning. The male lit...

journal_title：Neurotoxicology

authors： Carbone S,Szwarcfarb B,Ponzo O,Reynoso R,Cardoso N,Deguiz L,Moguilevsky JA,Scacchi P

更新日期：2010-12-01 00:00:00

abstract：:Environmental chemicals have a potential impact on children's health as the developing brain is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that very complex processes of cell development and maturation take place within a t...

journal_title：Neurotoxicology

authors： Bal-Price AK,Hogberg HT,Buzanska L,Lenas P,van Vliet E,Hartung T

更新日期：2010-09-01 00:00:00

abstract：:Cuprizone is used to obtain demyelination in mice. Cuprizone-treated mice show symptoms similar to several neurodegenerative disorders such as severe status spongiosus. Although it has a simple chemical formula, its neurotoxic mechanism is still unknown. In this work, we examined both physico-chemical properties and b...

journal_title：Neurotoxicology

authors： Benetti F,Ventura M,Salmini B,Ceola S,Carbonera D,Mammi S,Zitolo A,D'Angelo P,Urso E,Maffia M,Salvato B,Spisni E

更新日期：2010-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by extensive degeneration of dopaminergic neurons in the nigrostriatal system. Neurochemical and neuropathological analyses clearly indicate that oxidative stress, mitochondrial dysfunction, neuroinflammation and impairment of the u...

journal_title：Neurotoxicology

authors： Kanthasamy A,Jin H,Mehrotra S,Mishra R,Kanthasamy A,Rana A

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To investigate the nature of parkinsonism associated with liver cirrhosis, which entails examination of the integrity of the nigrostriatal dopaminergic system. METHODS:Consecutive patients who had concurrent liver cirrhosis and parkinsonism were investigated with MRI and dopamine transporter (DAT) single-pho...

journal_title：Neurotoxicology

authors： Kim JM,Kim JS,Jeong SH,Kim YK,Kim SE,Kim SH,Kim Y

更新日期：2010-08-01 00:00:00